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KMID : 0043320090320101379
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Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1379 ~ p.1384
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Kaempferol Glycosides with Antioxidant Activity from Brassica juncea
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Choi Jae-Sue
Jung Hyun-Ah
Woo Ju-Jung
Jung Mee-Jung
Hwang Geum-Sook
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Abstract
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From the leaves of Brassica juncea, three kaempferol glycosides, kaempferol-3-O-(2-O-sinapoyl)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside-7-O-β-D-glucopyranoside (1), kaempferol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside-7-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (2), and kaempferol-3-O-(2-O-sinapoyl)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside-7-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (3) were isolated and the structures elucidated on the basis of spectral and chemical evidences. Antioxidant activities were determined by measuring the scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO?). Compounds 1 and 3 showed good antioxidant activities with respective IC50 values of 28.61 and 36.93 μM toward DPPH; respective IC50 values of 9.79 and 11.40 μM toward ONOO?. However, compound 2 showed no DPPH scavenging activity and weak ONOO? scavenging activity with an IC50 value of 32.00 μM.
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KEYWORD
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Brassica juncea, Kaempferol glycoside, NMR, 1, 1-Diphenyl-2-picrylhydrazyl radical, Peroxynitrite
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